Chwast’s 1976 Spanish-language poster featuring a grid, each cell suggesting one of 12 everyday alternatives to cigarette-smoking, was one of several he designed for the American Cancer Society that year. In this composition, he uses his typically humorous comic-book style in pastel colors with bright-red lettering to engage viewers with a very serious subject. This was a big year for the American Cancer Society: on November 18, its California division had introduced its Great American Smokeout, helping nearly one million people to stop smoking for a day. The Smokeout became a national, annual event the following year, gradually leading to significant changes in behavior and the establishment of lifesaving legislation. (In 1983, Chwast was also commissioned to design a poster for the event.)